Icariin Supplementation Effects on Exercise Metabolism in Mice and Myotubes

9.7 KB of tabular data from a 2026 figshare publication by Zhengyuan Liu. The dataset likely contains results from a study where Icariin supplementation for 4 weeks improved exercise performance and metabolic efficiency in C57BL/6 mice and C2C12 myotubes. Findings suggest the flavonoid activates TFEB to promote mitochondrial clearance and a metabolic shift toward oxidative phosphorylation.

Use Cases

• Analyzing dose-dependent effects of Icariin on exercise performance metrics like VO2max and running time.
• Investigating correlations between mitophagy pathway activation and lactate reduction in muscle cells.
• Modeling the relationship between TFEB activation and metabolic reprogramming toward oxidative phosphorylation.

Strengths

• Data is associated with a detailed experimental methodology combining in vivo mouse models and in vitro cell systems.
• Results are linked to a specific molecular mechanism involving TFEB activation and mitophagy.
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 9.7 KB file size indicates a very limited data scope, likely containing summary results rather than raw observations.

Provenance

Source

figshare, author Zhengyuan Liu.

Collection Method

Integrated experimental approach using C57BL/6 mice and C2C12 myotube cell cultures, with physiological assessments, transcriptomics, and molecular biology techniques.

Time Range

Study period not specified; data published in 2026.

Freshness

Last updated 2026-04-13 05:45:52; freshness should be verified.

Geography

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