Hub Genes in Chronic Hepatitis B Immune-Active Phase from Transcriptomic Analysis

Four hub genes—CCR5, IL10RA, KCNA3, and SLC24A4—were identified as characteristic of the immune-active phase of chronic hepatitis B. This 11.2 KB Excel table presents results from integrated bioinformatics and machine learning analysis of transcriptomic dataset GSE230397, validated with scRNA-seq and clinical samples. Author Fangfang Li uploaded the dataset under a CC-BY-4.0 license in May 2026.

Use Cases

• Validate hub gene expression signatures for chronic hepatitis B phase classification based on the identified four genes.
• Investigate correlations between SLC24A4 expression and macrophage infiltration profiles based on the described immune infiltration analysis.
• Perform secondary analysis on the integrated DEG and WGCNA results mentioned in the description.
• Identify potential FDA-approved drug candidates targeting the hub gene SLC24A4 based on the virtual screening methodology.

Strengths

• Results are validated across multiple independent datasets (GSE230397, GSE182159, GSE283471) and by western blot analysis.
• Analysis integrates differential expression, WGCNA, and machine learning algorithms, as described in the methods.
• Dataset is openly available under a permissive CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are unknown; field semantics must be inferred after download.
• The 11.2 KB file size suggests a very limited scope, likely containing summary results rather than raw expression data.

Provenance

Source

figshare

Collection Method

Integrated bioinformatics and machine learning analysis of transcriptomic data, validated with scRNA-seq and clinical samples.

Time Range

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Freshness

Last updated 2026-05-04 05:31:05; freshness should be verified.

Geography

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