Marek's Disease Virus EV microRNA Profiles Under Interferon Treatment

Shuang Wei's dataset contains microRNA sequencing profiles from extracellular vesicles in chicken embryo fibroblast cells under four experimental conditions: control, MDV infection, interferon-alpha treatment, and co-treatment. The data, last updated on 2026-05-20, likely includes expression patterns of 65 key differentially expressed miRNAs identified as targeting the IFN-I signaling network. It is shared under a CC-BY-4.0 license.

Use Cases

• Identify differentially expressed microRNAs based on sequencing profiles from MDV-infected and interferon-treated cells.
• Predict target genes of dysregulated miRNAs within the type I interferon signaling network.
• Validate computational predictions of miRNA-target interactions, such as gga-miR-20a-5p targeting cGAS or gga-miR-148a-3p targeting TLR3.
• Analyze how viral infection counteracts host immune responses by reprogramming extracellular vesicle cargo.

Strengths

• The dataset is derived from a controlled experiment with four distinct biological conditions, enabling comparative analysis.
• It focuses on 65 key differentially expressed miRNAs with predicted roles in a specific biological pathway.
• The data is associated with experimental validation of specific miRNA-target interactions mentioned in the description.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.
• The 1.7 MB file size suggests a relatively small dataset, potentially limiting statistical power.

Provenance

Source

figshare

Collection Method

Small RNA sequencing of extracellular vesicles from chicken embryo fibroblast (DF-1) cells under controlled laboratory conditions.

Freshness

Last updated 2026-05-20 10:45:06; freshness should be verified.