Fasciola Hepatica Gut Glycoproteins Identified as Potential Vaccine Candidates

A 2026 dataset by Sonja G. Rechsteiner identifies 36 Fasciola hepatica gut-associated glycoproteins as potential vaccine candidates. The data was generated using lectin-affinity chromatography, monoclonal antibodies, and affinity-enrichment mass spectrometry. The research demonstrates the protective capacity of these antigens through in vitro feeding assays.

Use Cases

• Prioritizing vaccine candidate proteins based on the list of 36 identified glycoproteins.
• Studying parasite gut biology and host-parasite interactions based on the described glycoprotein characterization.
• Designing in vitro assays to test flukicidal activity based on the described monoclonal antibody feeding experiments.

Strengths

• Identifies a specific list of 36 candidate proteins for further vaccine development.
• Describes a multi-method experimental approach combining chromatography, monoclonal antibodies, and mass spectrometry.
• Released under a permissive CC-BY-4.0 license for open reuse.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is small (94.1 KB), indicating limited scope, likely a summary table rather than raw experimental data.

Provenance

Source

Sonja G. Rechsteiner, published on figshare.

Collection Method

Lectin-affinity chromatography, monoclonal antibody purification, and affinity-enrichment mass spectrometry proteomics.

Freshness

Last updated 2026-05-29 05:32:41.