DTI-ALPS Index Values for Alzheimer's Disease Continuum from Meta-Analysis

A systematic review and meta-analysis of 15 studies with 1,756 participants, published up to August 2025, investigates the DTI-ALPS index as a biomarker for glymphatic dysfunction in Alzheimer's disease. The dataset, authored by Zulin Liao and shared under a CC-BY-4.0 license, contains pooled results showing a stepwise decrease in ALPS values across cognitively normal controls, mild cognitive impairment, and Alzheimer's disease groups. The analysis was conducted according to PRISMA guidelines and registered with PROSPERO.

Use Cases

• Assessing the DTI-ALPS index as a non-invasive biomarker for glymphatic dysfunction based on the meta-analysis results.
• Comparing glymphatic system function across Alzheimer's disease, mild cognitive impairment, and cognitively normal control groups using the pooled mean differences.
• Evaluating the stability of imaging biomarker findings across heterogeneous study methodologies based on the described subgroup and sensitivity analyses.
• Supporting research into early detection and monitoring of Alzheimer's disease progression using MRI-derived markers.

Strengths

• Includes data from 15 studies and 1,756 participants, providing a substantial evidence base.
• Follows PRISMA guidelines for systematic review and meta-analysis, suggesting a structured methodology.
• Registered with PROSPERO (CRD420251119624), indicating transparency in the review process.
• Assessed risk of bias with the AHRQ checklist and evaluated certainty of evidence with GRADE.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a 17.5 KB DOCX file, indicating limited scope and likely containing summary tables rather than raw participant-level data.

Provenance

Source

Zulin Liao via figshare.

Collection Method

Systematic review and meta-analysis of studies from PubMed, Embase, Web of Science, Scopus, CENTRAL, and PEDro.

Time Range

Studies included up to August 2025.

Freshness

Last updated 2026-06-01 10:48:13; freshness should be verified.