Sjogren's Disease Interferon Ratios and Pain Severity

59 Sjogren's disease patients, 35 systemic lupus erythematosus patients, and 30 healthy controls were analyzed in a real-life exploratory study. Plasma concentrations of interferon subtypes were measured and ratios calculated to explore associations with disease activity and patient-reported pain. The dataset was published by Krzysztof Proc on figshare in April 2026.

Use Cases

• Correlating interferon subtype ratios with patient-reported pain severity based on ESSPRI scores
• Comparing interferon pathway balance patterns between Sjogren's disease and systemic lupus erythematosus
• Exploring interferon ratios as potential biomarkers for immune dysregulation in autoimmune conditions

Strengths

• Includes data from 124 participants across three distinct groups
• Analyzes five specific interferon subtypes (IFN-α2, IFN-β, IFN-γ, IFN-λ1, IFN-λ2)
• Uses established clinical assessment tools (ESSDAI, ESSPRI, SLEDAI-2K)

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is 691.4 KB, indicating a limited scope

Provenance

Source

figshare

Collection Method

Real-life exploratory study measuring plasma interferon concentrations

Freshness

Last updated 2026-04-10 08:46:11