Immune Correlates in Vaccine-Associated Small Fiber Neuropathy

Alessandro Limongelli published a clinical dataset on figshare in March 2026. It contains results from a study of 71 previously healthy patients with neurological symptoms following SARS-CoV-2 vaccination. The data includes biopsy results, antibody analyses, and flow cytometric measurements related to immune imbalances.

Use Cases

• Analyzing immune cell populations based on flow cytometric analysis of peripheral NKG2D+CD8+ and NKG2D+DNAM-1+CD4+ T-cells.
• Investigating antibody reactivity patterns based on anti-ACE-2 and anti-NRP-1 antibody ELISA results.
• Correlating symptom severity and onset timing based on reported median time from vaccination to symptom manifestation and symptom severity scores.
• Studying small fiber neuropathy pathology based on cutaneous biopsy results showing reduced small fiber density.

Strengths

• Includes data from 71 patient cases, providing a specific cohort size.
• Contains multiple measurement types: biopsy results from 21 patients, antibody analysis from 71 patients, and flow cytometry from 20 patients.
• Provides specific temporal metrics, such as median symptom onset time of 3 days and mean symptom severity score of 5.9.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is 20.7 KB, indicating a very limited scope and likely summary-level data.

Provenance

Source

Alessandro Limongelli via figshare.

Collection Method

Clinical study involving patient biopsies, blood sampling, ELISA, immunofluorescence, and flow cytometry.

Freshness

Last updated 2026-03-19 05:19:29.