Systematic Review of Immune Dysregulation in Tuberculosis-Diabetes Comorbidity

A systematic review synthesizing 81 studies published between 1974 and May 2023 on the immunological mechanisms linking diabetes mellitus and tuberculosis. The document, authored by Aminat Y. Saula, was last updated in April 2026. It examines how diabetes alters TB pathogenesis through immune dysregulation.

Use Cases

• Identify key immune pathways altered in TB-DM comorbidity based on the synthesis of 81 studies.
• Compare immunological profiles between active TB and latent TB infection in diabetic patients based on the review's findings.
• Explore potential host-directed therapeutic strategies for TB-DM patients based on the mechanistic insights discussed.
• Investigate the impact of pre-diabetes on TB immunity based on the emerging evidence highlighted in the review.

Strengths

• Systematic methodology covering 81 eligible studies identified from a defined period (1974-2023).
• Registered with PROSPERO (CRD42023431040), indicating a structured review protocol.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is a 20.0 KB DOCX document, indicating a limited scope of raw data.
• Row count and column-level documentation are unknown; the file contains a review article rather than structured data tables.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Systematic review of published studies.

Time Range

Studies published between 1974 and May 31, 2023.

Freshness

Last updated 2026-04-23 04:21:48; freshness should be verified.

Geography

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