Human Metapneumovirus Immune Evasion Mechanisms: Systematic Review

A systematic review of literature published up to March 1, 2025, analyzing immune evasion strategies of human metapneumovirus. The review, authored by Yuling Han and published in 2026, synthesized findings from 61 articles meeting inclusion criteria out of 1,322 retrieved. It describes a multi-layered evasion network targeting innate and adaptive immunity.

Use Cases

• Identify viral protein targets for antiviral drug development based on the described evasion mechanisms.
• Model host-pathogen interactions in respiratory infections based on the described network of immune suppression.
• Inform vaccine design strategies based on the analysis of antibody-mediated neutralization evasion.
• Guide research into non-coding RNA and epigenetic regulation in viral infections as described in the review.

Strengths

• Systematic methodology includes a search of three major databases (PubMed, Scopus, Web of Science).
• Quality assessment performed using multiple established guidelines (RTI Item Bank, CAMARADES, ARRIVE 2.0).
• Findings are based on 61 included articles, providing a synthesized evidence base.
• The review is registered with PROSPERO (CRD420251018019), enhancing transparency.

Limitations

• The dataset is a 502.5 KB DOCX file, suggesting limited scope as a review document rather than a primary data collection.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

Yuling Han via figshare

Collection Method

Systematic literature review

Time Range

Literature published up to March 1, 2025

Freshness

Last updated 2026-05-15 05:27:59