Immune Microenvironment Effects of Age-Associated Bifidobacterium Strains

Figshare data by Yaqin He details the immunomodulatory effects of Bifidobacterium adolescentis and Bifidobacterium longum subsp. infantis strains. The dataset contains results from transcriptomic and multi-omics analyses across mouse colitis, germ-free, and human cell co-culture models. It supports investigation into strain-specific cytokine signaling pathways and γδ T cell modulation.

Use Cases

• Analyze strain-specific changes in cytokine signaling pathways (e.g., NOD2-like, IL-17, TNF) from RNA-seq data post-probiotic treatment.
• Correlate Bifidobacterium strain administration (BA or BI) with γδ T cell infiltration levels in colorectal tissues from the DSS-induced colitis model.
• Model the differential activation of γδ T cells using data from direct co-culture experiments comparing BA and BI effects.
• Investigate multi-omics correlations between probiotic treatment and immune activation markers in peripheral blood.

Strengths

• Data originates from a structured study employing three distinct experimental models (DSS-induced colitis, germ-free, and in vitro co-culture).
• Includes results from transcriptomic (RNA-seq) and multi-omics correlation analyses.
• Released under a permissive CC BY 4.0 license for reuse.

Limitations

• The dataset is very small at 11.2 KB, indicating limited scope, likely summary statistics or key results rather than raw experimental data.
• Unknown row and column structure prevents assessment of sample size or feature granularity.

Provenance

Source

Yaqin He via figshare.

Collection Method

Experimental data from mouse models (DSS-induced chronic colitis, germ-free) and in vitro human intestinal γδ T cell co-culture systems, analyzed via transcriptomics and multi-omics.

Time Range

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Freshness

Last updated March 2026.

Geography

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