Memory T Cell Immunometabolic Profiles Linked to Tuberculosis Protection

Table 1_Immunometabolic reprogramming of Mycobacterium tuberculosis-responsive memory CD4+ T cell subsets is linked to long-term protective immunity.xlsx is a 1.5 MB Excel dataset published on figshare by Vaishnavi Kaipilyawar in April 2026. The data likely contains transcriptomic, metabolic, and functional profiles of memory T cell subsets from individuals with latent TB infection. It integrates RNA-sequencing, metabolic cytometry, and functional assay data, validated against a longitudinal cohort from Brazil.

Use Cases

• Classifying TB progression risk based on immunometabolic signatures described in the study.
• Modeling the relationship between T cell differentiation states and metabolic pathways like fatty acid oxidation and glycolysis.
• Identifying candidate biomarkers for next-generation TB vaccines from the linked transcriptomic and protein-level profiles.
• Analyzing longitudinal trends in T cell exhaustion and pro-inflammatory markers associated with disease progression.

Strengths

• Data integrates multi-platform validation, combining RNA-sequencing, metabolic cytometry, and functional assays.
• Findings are linked to an independent, longitudinal clinical cohort (GSE112104) of progressors and non-progressors.
• Dataset is shared under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the specific clinical cohorts studied.

Provenance

Source

figshare, author Vaishnavi Kaipilyawar.

Collection Method

Generated from a multi-platform study characterizing transcriptomic, metabolic, and functional programs of T cell subsets.

Time Range

null

Freshness

Last updated 2026-04-10 05:59:02; freshness should be verified.

Geography

Includes data from a longitudinal cohort in Brazil (GSE112104).