Central Obesity Impact on Esophageal Function from CT Analysis

Figshare hosts a clinical study dataset of 185 patients stratified by visceral-to-subcutaneous fat ratio (V/S) to investigate central obesity's impact. The data includes patient demographics, high-resolution manometry parameters, and 24-hour pH-impedance metrics. Jiang Guidong authored this 2026 study correlating V/S with metrics like lower esophageal sphincter pressure and acid exposure time.

Use Cases

• Correlate visceral-to-subcutaneous fat ratio (V/S) with lower esophageal sphincter (LES) resting pressure and esophagogastric junction contractile integral (EGJ-CI) to model obesity's mechanical impact.
• Analyze acid exposure time (AET) and DeMeester score (DMS) across V/S quartiles to assess mucosal barrier dysfunction linked to central obesity.
• Investigate associations between mean nocturnal baseline impedance (MNBI) Z3-Z6 and patient demographics like age and BMI within defined V/S groups.
• Build regression models using V/S, Hiatal Hernia status, and Bolus Clearance Time (BCT) to predict GERD prevalence outcomes.

Strengths

• Dataset contains results from 185 clinically characterized patients, providing a substantive sample for analysis.
• Includes multiple validated clinical metrics such as HRM parameters, 24-h pH-impedance data, and CT-derived fat ratios for multi-faceted assessment.
• Stratifies patients into four quartiles (Q1-Q4) based on a calculated V/S ratio, enabling comparative group analysis.

Limitations

• The dataset is very small at 13.9 KB, likely containing only summary or table data rather than raw patient-level records.
• As a retrospective study, it may contain selection bias and lacks longitudinal data to establish causality.
• Specific column definitions and raw sample data are unavailable, limiting direct analytical utility.

Provenance

Source

Figshare, authored by Jiang Guidong.

Collection Method

Retrospective clinical study combining fiberoptic gastroduodenoscopy, high-resolution manometry, 24-h pH-impedance monitoring, and non-contrast abdominal CT scans.

Freshness

Last updated in March 2026, indicating recent data.