Impact of Co-Pathologies on Cognitive Trajectory in Alzheimer's Disease

A retrospective neuropathological study of 77 participants from the ADNI database with intermediate to high levels of Alzheimer's disease neuropathological change. The dataset, authored by Jarok Koo and last updated in April 2026, examines the cross-sectional and longitudinal effects of Lewy body and TDP-43 co-pathologies on cognitive and neuropsychiatric symptoms.

Use Cases

• Modeling cognitive decline trajectories based on the presence of Lewy body co-pathology.
• Analyzing the association between TDP-43 co-pathology and specific neuropsychiatric symptoms like sleep disturbance.
• Investigating the differential impact of co-pathologies on memory, language, and executive function decline.
• Stratifying patient prognosis for personalized therapeutic strategies based on mixed neuropathology.

Strengths

• Dataset size of 77 participants with confirmed autopsy data provides a specific neuropathological cohort.
• Longitudinal clinical data allows for analysis of decline trajectories over time.
• Clear categorization of participants based on the presence or absence of two specific co-pathologies (LB-NC and LATE-NC).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 17.8 KB file size suggests a very limited scope, likely containing summary results rather than raw participant-level data.

Provenance

Source

ADNI (Alzheimer's Disease Neuroimaging Initiative) database.

Collection Method

Retrospective analysis of participants with available autopsy data.

Freshness

Last updated 2026-04-17 05:08:31