CLARA Registry: Pediatric Crohn's Disease Treatment Patterns and Guideline Adherence

170 pediatric patients diagnosed with Crohn's disease were analyzed from the CLARA cluster-randomized trial. The data compares initial treatment strategies, including exclusive enteral nutrition use, between centers using a patient registry and those using standard documentation. This secondary analysis, authored by L. Tischler and last updated in 2026, highlights a gap between guideline recommendations and real-world clinical practice.

Use Cases

• Compare real-world treatment patterns between intervention and control groups based on the registry-based feedback system.
• Analyze adherence to guideline-recommended exclusive enteral nutrition duration based on documented patient outcomes.
• Model factors associated with steroid use in the first 90 days post-diagnosis based on the reported patient cohorts.
• Investigate the association between automated clinical feedback and documented use of nutrition therapy.

Strengths

• Data originates from a cluster-randomized, controlled trial (DRKS00015505), suggesting a structured collection method.
• Includes specific patient counts for intervention (n=88) and control (n=82) groups diagnosed with Crohn's disease.
• Reports detailed statistical comparisons, such as steroid use frequency (p<0.028) and EN use trends.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale modeling.
• The dataset is very small (18.5 KB), indicating limited scope, likely containing summary results rather than patient-level records.

Provenance

Source

Secondary analysis of the CLARA cluster-randomized trial.

Collection Method

Data from a clinical trial where treatment providers documented care in the CEDATA-GPGE patient registry (intervention) or standard charts (control).

Time Range

Covers the first 90 days after diagnosis for enrolled patients.

Freshness

Last updated 2026-05-26 05:26:04; freshness should be verified.