NIPT and Ultrasound Soft Marker Data for Prenatal Risk Stratification

303 singleton pregnancies from a Chinese tertiary center between September 2022 and September 2025. This retrospective cohort study by Dan Fu integrates non-invasive prenatal testing (NIPT) results with second-trimester ultrasound soft markers to assess diagnostic accuracy for fetal chromosomal abnormalities.

Use Cases

• Modeling positive predictive value (PPV) improvement based on the integration of NIPT and ultrasound markers.
• Analyzing aneuploidy-type-specific phenotypic profiles for trisomies 21, 18, and 13.
• Evaluating diagnostic accuracy metrics like sensitivity, specificity, and AUC for combined strategies.
• Assessing the reduction of invasive procedures through individualized counseling based on marker counts.
• Studying the incremental benefit of combined testing for women under 35 years of age.

Strengths

• Includes 303 patient records with confirmed chromosomal abnormalities for 24 pregnancies (7.9%).
• Compares predefined combined strategies using diagnostic accuracy metrics and receiver operating characteristic analysis.
• Provides specific performance metrics: NIPT achieved 100% sensitivity, 55.8% PPV, and the combined model achieved an AUC of 0.987.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect geographic bias inherent to a single Chinese tertiary center.

Provenance

Source

figshare

Collection Method

Retrospective cohort study at a Chinese tertiary center.

Time Range

September 2022–September 2025

Freshness

Last updated 2026-05-29 04:45:18; freshness should be verified.

Geography

China (single tertiary center)