Table 1_In silico analysis of sarcomere length effects on myocardial contraction and cardi

A 22.0 KB document by Tae-Rim Kim, last updated in April 2026, presents an in silico analysis of cardiac sarcomere length parameters. The study uses the Living Left Heart Model in Abaqus to simulate how variations in unloaded sarcomere length (Lr) and zero active tension length (L0) affect tissue-level tension and organ-level cardiac pump performance.

Use Cases

• Calibrating time-varying-elastance-based myocardial models based on sarcomere length parameters Lr and L0.
• Simulating sarcomere-related cardiomyopathies based on described parameter variations affecting contractility and diastolic function.
• Investigating the multiscale link between sarcomere mechanics and organ-level pump performance based on simulated pressure-volume loops and regional strain.
• Exploring the mechanistic role of the sarcomere length difference (SLD) in determining peak active stress based on the findings.

Strengths

• Document is under a permissive CC-BY-4.0 license.
• The description provides specific parameter ranges for Lr (1.75 to 1.95 µm) and L0 (1.48 to 1.68 µm).
• Analysis spans from tissue-scale length-tension relationships to organ-level cardiac function metrics.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a 22.0 KB DOCX file, indicating a limited scope focused on textual analysis rather than raw simulation data.

Provenance

Source

figshare

Collection Method

In silico simulation using the Living Left Heart Model implemented in Abaqus.

Time Range

Simulation study, no specific temporal coverage for observational data.

Freshness

Last updated 2026-04-10 05:59:14; freshness should be verified.

Geography

Simulation study, no specific geographic coverage.