Table 1_In silico design and experimental validation of a multi-epitope vaccine candidate

A research document detailing the design and validation of a multi-epitope vaccine candidate against Helicobacter hepaticus. The study employed reverse vaccinology, molecular docking, dynamics simulations, and in vitro immunological assays. The document was authored by Liangliang Weng and last updated on 2026-04-30.

Use Cases

• Study reverse vaccinology workflows based on the description of conserved outer membrane protein selection.
• Analyze predicted T-cell epitopes for immunogenicity and safety based on the described screening process.
• Evaluate structural vaccine candidate properties based on the described modeling, docking, and molecular dynamics simulations.
• Assess in vitro vaccine immunogenicity based on described PBMC proliferation, T-cell activation, and cytokine secretion assays.

Strengths

• The description provides a detailed methodological account of the vaccine design and validation pipeline.
• The document is licensed under CC-BY-4.0, permitting open sharing and adaptation.
• Specific target proteins (BamA and an organic solvent tolerance protein) and an adjuvant (human β-defensin-3) are named.

Limitations

• The dataset is a 2.0 MB DOCX file, which is a small document format not containing raw structured data tables.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

figshare

Collection Method

Integrated reverse vaccinology and experimental validation, as described in the document.

Freshness

Last updated 2026-04-30 05:41:29; freshness should be verified.