Table 1_In silico identification and experimental validation of shared genes and explorati

Five upregulated common genes (MS4A2, TPSAB1, FCER1A, TFF3, TSPAN13) were identified from transcriptomics data of bronchial biopsy samples. The dataset, a 15.9 KB DOCX file, contains research findings on shared molecular mechanisms between type 2 and non-type 2 asthma. Author Zaixing Jia uploaded the work to figshare under a CC-BY-4.0 license, with a last update timestamp of 2026-05-08.

Use Cases

• Validate potential diagnostic biomarkers for asthma subtypes based on the five identified upregulated genes.
• Investigate shared immune cell infiltration patterns, such as mast cell activation, across different asthma inflammatory phenotypes.
• Explore gene ontology and pathway enrichment for the identified genes to understand underlying molecular mechanisms.
• Benchmark computational predictions from transcriptomics data against experimental RT-qPCR validation results.

Strengths

• Identifies five specific upregulated genes (MS4A2, TPSAB1, FCER1A, TFF3, TSPAN13) with diagnostic accuracy for asthma subtypes.
• Research methodology is detailed, including transcriptomics analysis, immune infiltration, and experimental validation via RT-qPCR.
• Dataset is openly shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a 15.9 KB DOCX document, which is a very small text file likely containing only summary results, not the underlying raw or processed data tables.
• Row count and column-level documentation are unknown, limiting assessment of the data's scale and structure.
• Freshness should be verified as the last update is timestamped for a future date (2026-05-08).

Provenance

Source

Transcriptomics data sourced from the Gene Expression Omnibus (GEO); research findings compiled by author Zaixing Jia.

Collection Method

Bioinformatic analysis of bronchial biopsy samples, intersected to find common genes, followed by experimental validation in mice models.

Freshness

Last updated 2026-05-08 13:48:49; freshness should be verified.