Table 1_In vivo CRISPR-mediated activation of cardiogenic genes to reprogram cardiac fibro

A 23.9 KB document authored by Suchandrima Dutta and last updated on 2026-04-22 describes a CRISPR activation study. The research validated a method for reprogramming cardiac fibroblasts into cardiovascular lineages using a CRISPRa system in transgenic mice following myocardial infarction. The dataset is a single DOCX file containing the study's Table 1, released under a CC-BY-4.0 license.

Use Cases

• Validate CRISPRa-mediated gene activation protocols based on the described Gata4, Nkx2.5, Tbx5, Isl1, and Smarcd3 (GNTIS) targets.
• Study cardiac fibroblast plasticity and transdifferentiation into cardiomyocyte-like or vascular smooth muscle cell-like lineages based on the in vivo model.
• Analyze hemodynamic parameters and cardiac function preservation following myocardial infarction based on the described experimental results.
• Develop foundational proof-of-concept models for in vivo cellular reprogramming based on the described CRISPRa transgenic system.

Strengths

• The dataset is a structured document from a specific, peer-reviewed-style research study.
• The description provides detailed methodological context, including the use of transgenic dCas9 mice and adeno-associated viral vectors (AAVs).
• The license is clearly stated as CC-BY-4.0, allowing for open reuse.

Limitations

• The dataset is a single 23.9 KB DOCX file, indicating a very limited scope, likely containing only one table.
• Column-level documentation is absent; field semantics must be inferred from the surrounding text after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Generated from a research study involving CRISPR activation in transgenic mice.

Freshness

Last updated 2026-04-22 05:49:27; freshness should be verified.