Structured Transition Protocol for Paediatric Patients with Inborn Errors of Immunity

A practice-informed narrative review proposes a structured, multidisciplinary transition protocol for paediatric patients with inborn errors of immunity. The model, developed by Adele Civino and integrating literature, expert consensus, and experience from a dedicated Italian centre, includes early patient identification around age 14 and a transition overlap period of at least three years. It was last updated on 2026-05-11.

Use Cases

• Designing a standardized clinical dossier based on the described framework for patient handover.
• Evaluating transition program outcomes based on proposed indicators like infection rates and follow-up adherence.
• Planning multidisciplinary team involvement based on the model's shared responsibility and overlap period.
• Assessing immunoglobulin replacement therapy options (intravenous, subcutaneous, facilitated subcutaneous) for transitioning patients.

Strengths

• The protocol is detailed, specifying an early identification age of around 14 and an overlap period of at least three years.
• It integrates multiple sources: a non-systematic literature review, expert clinical consensus, and practical experience from a dedicated Italian centre.
• The framework includes measurable process and outcome indicators, such as infection rates and patient-reported quality of life.

Limitations

• The dataset is a 25.0 KB DOCX file, indicating a limited scope focused on a narrative review and proposed model rather than extensive raw data.
• Row count and column-level documentation are absent; the content is textual and conceptual.
• The authors acknowledge limitations including reliance on multidisciplinary resources and the absence of prospective validation.

Provenance

Source

Adele Civino via figshare.

Collection Method

Practice-informed narrative review integrating literature appraisal, expert consensus, and clinical experience.

Freshness

Last updated 2026-05-11 04:20:58.

Geography

The model incorporates experience from a dedicated Italian centre, but its applicability is intended to be broader.