B-Cell and Cytokine Profiles in 272 ART-Treated HIV Patients with EBV Coinfection

272 patients living with HIV from Hospital Universitario San Ignacio in Bogotá, Colombia, were analyzed for B lymphocyte subpopulations, immunoglobulin isotypes, cytokines, and EBV viral load. The dataset, authored by Niyireth Peñaloza and last updated in March 2026, shows incomplete B-cell reconstitution after antiretroviral therapy, linked to EBV coinfection and lymphoma progression. Measurements were taken using next-generation flow cytometry, multiplex assays, and quantitative PCR.

Use Cases

• Modeling the relationship between B-cell subpopulation depletion and clinical HIV stage based on flow cytometry data.
• Analyzing cytokine profiles to identify inflammatory signatures associated with EBV coinfection.
• Investigating correlations between EBV viral load, memory B-cell loss, and lymphoma progression.
• Studying the long-term effects of antiretroviral therapy duration on B-cell reconstitution phenotypes.

Strengths

• Includes data from 272 patients, providing a substantive clinical cohort.
• Multimodal measurements: B-cell subpopulations, cytokines, and EBV viral load from a single study.
• Patients are categorized by clinical stage, disease category, time on ART, and EBV coinfection status.

Limitations

• Row and column counts are unknown, limiting suitability assessment for specific analytical tasks.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is from a single hospital in Colombia, which may limit generalizability to other populations.

Provenance

Source

figshare, authored by Niyireth Peñaloza.

Collection Method

Clinical study analyzing patient samples with flow cytometry, multiplex assays, and PCR.

Freshness

Last updated 2026-03-18 05:21:11.

Geography

Bogotá, Colombia (Hospital Universitario San Ignacio).