Fibrinogen-to-Albumin Ratio for Predicting Adverse Perinatal Outcomes in Preeclampsia

A dual-center retrospective cohort study of 924 preeclamptic patients from two tertiary referral hospitals. The dataset supports the evaluation of the fibrinogen-to-albumin ratio (FAR) as an incremental prognostic marker for a composite adverse perinatal outcome. The study includes training, internal validation, and independent external validation cohorts, with model performance assessed using AUC, NRI, and IDI metrics.

Use Cases

• Validate the incremental prognostic value of the fibrinogen-to-albumin ratio (FAR) for adverse perinatal outcomes based on the described model comparison.
• Train logistic regression models for composite outcome prediction using established predictors like the sFlt-1/PlGF ratio as mentioned in the description.
• Assess model calibration and discrimination performance using metrics like AUC, Brier score, and net reclassification improvement detailed in the results.
• Explore the utility of a specific FAR cutoff (0.135) for guiding anesthesia and perioperative care decisions in preeclamptic patients.

Strengths

• Dataset includes 924 patient records from two independent centers, providing internal and external validation cohorts.
• Model performance is rigorously quantified with specific metrics, including an AUC of 0.888 for the extended model in the training cohort.
• The study defines a clear composite adverse perinatal outcome (CAPO) encompassing eight specific clinical events.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying data tables is unknown, which may limit suitability assessment.
• The dataset is very small at 16.8 KB, indicating limited raw data scope, likely containing summary results or a single table.

Provenance

Source

figshare

Collection Method

Dual-center retrospective cohort study.

Freshness

Last updated 2026-05-29 04:50:31; freshness should be verified.

Geography

Patients from two tertiary referral hospitals (centers A and B); specific locations unknown.