Blautia and IAA Effects on Sepsis-Induced Lung Injury

A research document analyzes the role of the gut bacterium Blautia and its metabolite indole-3-acetic acid (IAA) in sepsis-induced acute lung injury. The study uses data from sepsis patients and a rat model to show that Blautia depletion correlates with disease severity and that supplementation improves outcomes. It was authored by Ke Chao and published in March 2026.

Use Cases

• Analyze the correlation between Blautia abundance and pulmonary injury severity in sepsis patient data.
• Investigate the relationship between indole-3-acetic acid (IAA) levels and CD8+ T cell functional responses in experimental models.
• Study the therapeutic effects of Blautia supplementation on survival rates in a cecal ligation and puncture rat model.

Strengths

• Data originates from a peer-reviewed research study combining clinical patient analysis and controlled animal model experiments.
• The dataset is openly available under a CC BY 4.0 license, permitting broad reuse.

Limitations

• The dataset is a 15.2 KB DOCX file, containing textual research results rather than structured, machine-readable tabular data.
• No columnar data or sample records are provided, limiting direct computational analysis.

Provenance

Source

figshare, authored by Ke Chao.

Collection Method

Research combining gut microbiome profiling of sepsis patients and healthy controls, untargeted metabolomic analysis, and functional studies in a rat model of sepsis.

Freshness

Last updated in March 2026.