Indoleamine 2,3-Dioxygenase-Regulated Macrophage Metabolic Reprogramming Data

A 23.1 KB document by Menghan Ye, last updated March 2026, investigates tacrolimus-induced nephrotoxicity. The study explores how tacrolimus suppresses IDO1 activity, blocking tryptophan-to-kynurenine conversion and impairing de novo NAD+ synthesis. It is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Modeling metabolic pathway disruption based on described tryptophan-to-kynurenine conversion impairment.
• Analyzing macrophage polarization shifts based on described changes in fatty acid oxidation and glycolysis.
• Investigating therapeutic interventions based on described exogenous kynurenine supplementation or PPARα activation.

Strengths

• File size is precisely 23.1 KB.
• License is explicitly CC-BY-4.0, permitting reuse with attribution.
• Last update date is specified as 2026-03-18.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 23.1 KB, indicating limited scope.

Provenance

Source

figshare, author Menghan Ye.

Collection Method

Likely contains experimental results from a study on tacrolimus-induced nephrotoxicity.

Freshness

Last updated 2026-03-18 06:42:22; freshness should be verified.