Infant-Derived Bifidobacterium Strains Screened for E. coli Inhibition

Wenqing Lv published a dataset on figshare in May 2026 detailing an in vitro screen of 38 Bifidobacterium strains isolated from healthy breastfed infants. The data likely contains results from antagonism assays, probiotic property evaluations, and follow-up in vivo animal experiments comparing selected strain D2 against a control. The study identified acetic acid as the main antibacterial substance and multiple mechanisms of E. coli inhibition.

Use Cases

• Screen for probiotic candidates based on in vitro antagonism against E. coli.
• Compare probiotic properties of different bacterial strains isolated from infant sources.
• Investigate mechanisms of pathogen inhibition, such as biofilm disruption and cell wall damage.
• Analyze the impact of probiotic strains on gut microbiota composition and cytokine expression.

Strengths

• The dataset is based on a specific screen of 38 distinct Bifidobacterium strains.
• Results include follow-up in vivo animal experiments comparing an effective strain (D2) with a control strain (A14).
• The study identifies a specific antibacterial substance (acetic acid) and multiple mechanisms of action.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The data is contained in a DOCX file (1.4 MB), which may require parsing to extract structured information.

Provenance

Source

figshare

Collection Method

38 Bifidobacterium strains were isolated from healthy breastfed infants and evaluated in vitro and in vivo.

Freshness

Last updated 2026-05-15 05:41:07; freshness should be verified.