Infection-Associated sTNFR1 Elevation Predicts Post-Transplant Thrombotic Microangiopathy

Ruiqing Zhou's dataset on figshare, last updated April 27, 2026, contains clinical biomarker data from a prospective nested case-control study of patients with severe aplastic anemia undergoing allogeneic hematopoietic stem cell transplantation. The data likely includes longitudinal measurements of soluble tumor necrosis factor receptor 1 (sTNFR1) and other biomarkers collected before and after transplantation. The study associated elevated pretreatment sTNFR1 levels with a significantly higher risk of transplant-associated thrombotic microangiopathy and mortality.

Use Cases

• Predicting risk of transplant-associated thrombotic microangiopathy based on pretreatment sTNFR1 biomarker levels.
• Analyzing the association between pre-transplant infections and post-transplant complications using biomarker data.
• Building survival models for post-transplant mortality based on hazard ratios derived from sTNFR1 levels.
• Assessing the predictive performance of clinical biomarkers using receiver operating characteristic analysis metrics.

Strengths

• Data is from a prospective nested case-control study design, which suggests a structured approach to biomarker comparison.
• Specific predictive performance metrics are provided, including an area under the curve of 0.76 and a hazard ratio of 6.78 for TA-TMA prediction.
• The dataset includes a defined biomarker cutoff value of 1.93 ng/mL for sTNFR1 with associated specificity (0.88) and sensitivity (0.69).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for machine learning tasks.
• The data file is a 12.5 MB DOCX document, which may require parsing to extract structured data.

Provenance

Source

figshare, author Ruiqing Zhou.

Collection Method

Data likely collected from blood samples in a clinical study of patients with severe aplastic anemia undergoing allo-HSCT.

Freshness

Last updated 2026-04-27 04:11:21; freshness should be verified.