Bovine Serum Extracellular Vesicle Protein Signatures for Mycoplasma Bovis Infection

Mallory A. Ross's dataset contains proteomic data from small extracellular vesicles isolated from dairy cow serum. The data compares protein cargo from 45 M. bovis infected cows and 49 non-infected controls, identifying 695 non-redundant proteins. Differential analysis highlighted 90 proteins with significant abundance changes associated with inflammation and oxidative stress pathways.

Use Cases

• Identify potential protein biomarkers for subclinical M. bovis infection based on differential protein abundance analysis.
• Investigate the role of inflammation and complement system proteins in bovine disease states.
• Explore small extracellular vesicle (sEV) biology during Mycoplasma bovis infection in cattle.
• Validate mass spectrometry findings for veterinary diagnostic assay development.

Strengths

• Includes data from a substantial sample size of 94 cows (45 infected, 49 controls).
• Identifies 695 non-redundant proteins and 90 significantly differentially abundant proteins.
• Data is licensed under CC-BY-4.0, allowing for open reuse and sharing.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is very small at 10.4 KB, indicating limited scope.
• Data may reflect geographic or herd bias inherent to the specific study sample.

Provenance

Source

figshare

Collection Method

Proteins were identified using liquid chromatography–ion mobility–tandem mass spectrometry on pooled serum samples.

Freshness

Last updated 2026-05-15 04:23:06

Geography

Likely New Zealand, based on the description mentioning its importance for eradication programs there.