Table 1_Inflammatory protein mediators linking gut microbiota to degenerative lumbar spine

473 genetically predicted gut microbiota taxa and 91 circulating inflammatory proteins were analyzed for causal links to three degenerative lumbar spine disorders using FinnGen R12 summary statistics. The dataset includes results from two-sample and two-step Mendelian randomization mediation analyses, with experimental validation from rat models. It was authored by Yongfu Lou and last updated on June 3, 2026.

Use Cases

• Identify candidate inflammatory protein mediators for mechanistic studies based on the 13 genetically supported GM–IPs–DLSD pathways.
• Validate genetic associations between specific gut microbiota taxa and spinal disorders like lumbar spinal stenosis, spondylolisthesis, and intervertebral disc disorders.
• Prioritize targets for translational research based on mediation proportions ranging from 7.55% to 13.22% for key pathways.
• Compare human genetic evidence with experimental models using the described qPCR, ELISA, and metagenomic sequencing results from rat studies.

Strengths

• Analysis is based on a large-scale genetic resource, specifically FinnGen R12 summary statistics.
• The study evaluates a high number of potential mediators, including 473 gut microbiota taxa and 91 inflammatory proteins.
• Findings are supported by complementary sensitivity analyses, pleiotropy testing, and experimental validation in animal models.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 6.7 MB DOCX document, which may require parsing to extract structured results.

Provenance

Source

figshare

Collection Method

Two-sample Mendelian randomization using summary statistics from the FinnGen R12 cohort, supplemented by experimental validation in rat models.

Freshness

Last updated 2026-06-03 04:47:14; freshness should be verified.