Table 1_Influenza vaccination and cardiovascular and respiratory outcomes in high-risk pop

Fourteen systematic reviews and meta-analyses covering over 230 million participants were synthesized in this umbrella review. The review, authored by Chengyan Jin and last updated in May 2026, critically evaluates evidence on influenza vaccination effectiveness and safety in high-risk populations. It assesses outcomes including major cardiovascular events, mortality, and COPD exacerbations.

Use Cases

• Assessing the association between influenza vaccination and major adverse cardiovascular events based on evidence from patients with ischemic heart disease.
• Evaluating the impact of vaccination on respiratory outcomes based on data for COPD exacerbations and influenza incidence in older adults.
• Analyzing safety profiles of influenza vaccines based on the review's synthesis of serious adverse event data across a large evidence base.
• Comparing evidence certainty for different health outcomes based on the application of GRADE and AMSTAR-2 assessment frameworks.

Strengths

• Synthesizes evidence from 14 systematic reviews and meta-analyses.
• Evidence base covers more than 230 million participants.
• Explicitly addresses review quality, overlap, and certainty using AMSTAR-2 and GRADE.

Limitations

• Dataset is a single 18.2 KB DOCX file, indicating a very limited scope of raw data.
• The description is detailed but no underlying column-level data or sample records are provided.
• Row count and specific data structure are unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Umbrella review of systematic reviews and meta-analyses identified through PubMed, Embase, and the Cochrane Library.

Time Range

Reviews from database inception to December 1, 2025.

Freshness

Last updated 2026-05-26 06:02:10