STING Inhibition Effects on Viral Hepatitis and Liver Damage in Mouse Models

Yize Zhang's dataset, last updated April 28, 2026, accompanies a study on the STING-lipotoxicity axis in viral hepatitis. It includes experimental data from primary mouse hepatocyte and in vivo mouse models, alongside clinical correlation data from the NHANES survey (2007–2010). The dataset is 19.2 KB in size and shared under a CC-BY-4.0 license.

Use Cases

• Analyze the correlation between fatty liver index and liver injury biomarkers based on the NHANES data mentioned in the description
• Investigate the time-dependent activation of the STING pathway in viral-infected hepatocytes based on the described experimental model
• Evaluate the protective effects of STING inhibition (H-151) on cell viability and metabolic stress based on the described genetic and pharmacological interventions
• Model the relationship between triglyceride levels and aminotransferase (ALT/AST) levels in patients with viral hepatitis and MASLD based on the described clinical findings

Strengths

• Includes clinical correlation data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007–2010.
• Combines in vitro (primary mouse hepatocyte) and in vivo (mouse model) experimental data on a specific molecular pathway.
• Dataset is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is very small (19.2 KB), indicating limited scope and likely a summary of key results rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

Yize Zhang, via figshare.

Collection Method

Data generated from laboratory experiments using primary mouse hepatocyte and mouse models, combined with analysis of publicly available NHANES survey data.

Time Range

Experimental data time range is unspecified. Clinical correlation data is from NHANES 2007–2010.

Freshness

Last updated 2026-04-28 06:33:22; freshness should be verified.

Geography

Laboratory data likely from a single research institution. NHANES data covers the United States.