NK Cell Profiles in Hypertensive and Normotensive Males from CyTOF and Flow Cytometry

Mass cytometry and flow cytometry data profiling innate immune cells from 10 hypertensive and 10 normotensive male subjects, with validation in an independent cohort of 10 hypertensive and 6 normotensive males. The dataset, authored by Xiaoqi Wang and last updated in April 2026, focuses on the specific reduction of a CD57+CD62L+CD161+ natural killer cell subpopulation in hypertensive patients. Single-cell RNA sequencing data further delineates transcriptional heterogeneity within this NK cell subset.

Use Cases

• Identify immune cell signatures associated with hypertension based on high-dimensional mass cytometry profiles.
• Validate flow cytometry findings for specific NK cell subpopulations in an independent patient cohort.
• Analyze transcriptional heterogeneity and subset composition shifts using single-cell RNA sequencing data.
• Investigate mechanisms of NK cell depletion linked to impaired IL-15 signaling pathways.

Strengths

• Data is validated across two independent cohorts totaling 36 male subjects.
• Profiling employs multiple high-resolution techniques: mass cytometry, flow cytometry, and single-cell RNA sequencing.
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• Data is limited to male subjects, which may restrict generalizability.
• The dataset is small in size (26.2 KB), indicating limited scope.

Provenance

Source

figshare, author Xiaoqi Wang.

Collection Method

High-dimensional mass cytometry (CyTOF), full-spectrum flow cytometry, and single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs).

Time Range

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Freshness

Last updated 2026-04-16 05:25:54; freshness should be verified.

Geography

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