Table 1_Insights into the effects of gut microbiota and circulating metabolites on oral ca

A dataset containing results from a bidirectional two-sample Mendelian randomization analysis exploring causal links between gut microbiota, circulating metabolites, and oral cancer. It includes findings from 471 gut microbial taxa and 233 circulating metabolites derived from genome-wide association studies, validated with clinical samples. The dataset was authored by Junfeng Guo and last updated on 2026-05-21.

Use Cases

• Identify potential causal gut microbial taxa for oral cancer based on odds ratios and p-values.
• Investigate mediating roles of specific circulating metabolites like citrate and omega-3 fatty acids in the gut-oral cancer pathway.
• Validate Mendelian randomization findings using clinical multi-omics profiling data referenced in the study.

Strengths

• Includes results for 471 gut microbial taxa and 233 circulating metabolites from GWAS sources.
• Analysis employed multiple MR methods (IVW-MR, GSMR) and tested for pleiotropy and heterogeneity.
• Findings were validated with additional clinical samples, as mentioned in the description.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific GWAS sources used.

Provenance

Source

Genome-wide association studies (GWAS) for gut microbiota, circulating metabolites, and oral cancer.

Collection Method

Bidirectional two-sample Mendelian randomization analysis with clinical validation.

Freshness

Last updated 2026-05-21 05:45:52; freshness should be verified.