Autism Risk Genes with m6A Enrichment Analysis from SFARI Database

This dataset integrates m6A-seq and CLIP-seq data with the SFARI gene database, finding that 41.59% (515 of 1,238 genes) of autism risk genes are m6A-enriched. It specifically identifies 28 syndromic genes overlapping with the Synaptic m6A Epitranscriptome (SME). The analysis was authored by Shreya Doijad and focuses on m6A readers like FMRP and YTHDF1.

Use Cases

• Identify m6A-enriched ASD risk genes from the SFARI gene database for functional enrichment studies.
• Analyze the overlap between syndromic genes and the Synaptic m6A Epitranscriptome (SME) to prioritize candidate genes.
• Investigate the role of specific m6A readers like FMRP and YTHDF1 in synaptic regulation within the context of autism.

Strengths

• Analysis is based on 1,238 genes from the authoritative SFARI gene database.
• Quantifies m6A enrichment with a specific finding: 515 genes (41.59%) of ASD risk genes are m6A-enriched.
• Focuses on a specific molecular mechanism (m6A) and synaptic context relevant to neurodevelopmental disorders.

Limitations

• The dataset is very small (7.7 KB), suggesting it contains summary or processed results, not raw genetic data.
• The specific columns, rows, and sample data are unknown, limiting direct analytical utility.
• The analysis is a static integration of previously published data; it does not provide new primary sequencing data.

Provenance

Source

Integration of previously published m6A-seq and CLIP-seq data with the SFARI gene database.

Collection Method

Bioinformatic integration and analysis of public genomic datasets.

Freshness

Last updated 2026-03-20.