TP53 His179 Mutation Analysis in NSCLC: Structural and Genomic Characterization

616 lung adenocarcinoma (LUAD) and 544 lung squamous cell carcinoma (LUSC) patient mutational profiles from TCGA were analyzed by Ankur Datta, with results last updated in April 2026. The study focuses on specific mutations at the His179 residue in the TP53 zinc-binding motif, evaluating their structural impact via molecular dynamics simulations. It reports TP53 mutations in 50% of LUAD and 81% of LUSC cases, with C > A as the predominant substitution.

Use Cases

• Analyze mutation frequency and type at the TP53 His179 locus based on cohort data from 1,160 NSCLC patients.
• Model structural perturbations in protein loops L1 and L2 based on conformational signatures from molecular dynamics simulations.
• Assess changes in zinc-binding affinity and protein stability based on energy landscape and contact map analyses for specific H179 variants.
• Compare mutational profiles and structural consequences between LUAD and LUSC subtypes based on the described cohort analysis.

Strengths

• Focuses on a specific, underexplored structural site (His179) within a critical tumor suppressor protein.
• Analyzes a combined cohort of 1,160 NSCLC patients (616 LUAD, 544 LUSC) from TCGA.
• Employs a multi-method approach combining genomic analysis with atomistic molecular dynamics simulations.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (14.7 KB), suggesting it likely contains summary results or a single table rather than raw genomic data.
• Description metadata is limited; actual data quality and completeness require manual inspection after download.

Provenance

Source

TCGA (The Cancer Genome Atlas) mutational profiles, analyzed by author Ankur Datta.

Collection Method

Genomic evaluation of patient profiles combined with static structural analysis and molecular dynamics simulations.

Time Range

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Freshness

Last updated 2026-04-10 05:59:23; freshness should be verified.

Geography

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