Sivelestat Mechanisms in Myocarditis: Pharmacology and Mouse Model Data

Experimental data from a study investigating the cardioprotective mechanisms of the neutrophil elastase inhibitor Sivelestat in a mouse model of autoimmune myocarditis. The dataset, shared by Ruguo Ren on figshare under CC-BY-4.0, includes computational network pharmacology results and in vivo experimental measurements from male BALB/c mice treated with Sivelestat. It was last updated on April 30, 2026.

Use Cases

• Validate network pharmacology predictions based on shared targets between Sivelestat and myocarditis.
• Analyze dose-response relationships based on Sivelestat administration at 50, 100, and 200 mg/kg/day.
• Study correlations between inflammatory markers like serum IL-1β, IL-6, TNF-α, and cardiac function parameters.
• Investigate the role of the PI3K-Akt signaling pathway in reducing cardiomyocyte apoptosis based on Western blot data.

Strengths

• Includes data from a controlled in vivo experiment with 6 mice per treatment group.
• Integrates computational (41 potential targets identified) and experimental validation methods.
• Contains specific molecular binding affinity data, such as PTGS2 at -9.0 kcal/mol.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 10.2 KB, indicating limited scope.

Provenance

Source

figshare, author Ruguo Ren

Collection Method

Data generated from a combined computational network pharmacology and experimental mouse model study.

Freshness

Last updated 2026-04-30 04:17:51; freshness should be verified.