Table 1_Integrated transcriptome and single-cell RNA sequencing identifies small GTPase-as

Table 1_Integrated transcriptome and single-cell RNA sequencing identifies small GTPase-associated biomarkers in ulcerative colitis.csv is a 10.2 KB dataset by Meilin Chen, last updated in April 2026. It contains results from a study that integrated multiple transcriptomic datasets and used machine learning to identify diagnostic biomarkers for ulcerative colitis.

Use Cases

• Training diagnostic models for ulcerative colitis based on the identified biomarkers ARHGEF3, S100A8, and RHOU.
• Analyzing immune cell infiltration and macrophage heterogeneity in UC based on the single-cell RNA sequencing results mentioned.
• Investigating the role of small GTPase-related genes in inflammatory pathways like 'Tight junction' and 'Leukocyte transendothelial migration'.
• Differentiating ulcerative colitis from Crohn's disease using the biomarker expression patterns described.

Strengths

• Biomarkers were validated across multiple independent cohorts with reported diagnostic AUC values up to 0.991.
• Study employed four machine learning algorithms and external validation, suggesting a rigorous analytical approach.
• Findings are linked to clinical severity and pathological states, indicating potential clinical relevance.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset is very small at 10.2 KB, indicating it likely contains summary results rather than raw sequencing data.
• Description metadata is limited; actual data structure and field semantics must be inferred after download.

Provenance

Source

Meilin Chen via figshare

Collection Method

Integrated analysis of multiple transcriptomic datasets and single-cell RNA sequencing, validated with in vivo experiments.

Time Range

null

Freshness

Last updated 2026-04-22 05:49:10; freshness should be verified.

Geography

null