Integrated Transcriptome-Microbiome Analysis of Insecticide Resistance in Aedes albopictus

An integrated analysis of transcriptome and gut microbiome data from Aedes albopictus mosquito populations in China, investigating mechanisms of insecticide resistance. The dataset includes results from bioassays, kdr mutation detection, and 16S rRNA sequencing for populations from five sites in Guangdong and Hainan provinces. It was authored by Lifang Liu and last updated on 2026-04-22.

Use Cases

• Correlating gut microbiome composition with insecticide resistance levels based on 16S rRNA sequencing data
• Identifying differentially expressed genes associated with pyrethroid resistance based on transcriptome analysis
• Analyzing the frequency and distribution of kdr mutations in field mosquito populations
• Investigating the role of specific bacterial genera like Cedecea in modulating host resistance through dietary supplementation assays

Strengths

• Includes data from five distinct field populations, allowing for comparative analysis
• Integrates multiple data types: bioassay results (resistance ratios from 2.84 to 29.18), mutation frequencies (49.4% to 100.0%), transcriptomics (2,566 commonly upregulated genes), and microbiome profiling
• Contains experimental validation data, such as a dietary supplementation assay showing a significant survival increase (73.86% vs 40.00%)

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is small (11.2 KB), indicating a limited scope, likely containing summary results rather than raw sequencing data

Provenance

Source

figshare

Collection Method

Mosquito populations were collected from field sites, with resistance determined via bioassays. Transcriptome and 16S rRNA sequencing were performed, followed by correlation analysis and dietary supplementation assays.

Freshness

Last updated 2026-04-22 05:46:36; freshness should be verified

Geography

Five sites in Guangdong and Hainan provinces, China