Table 1_Integrated transcriptomic profiling of programmed cell death patterns unveils macr

Table 1 from a study by Manling Xie, last updated May 2026, presents integrated transcriptomic profiling of programmed cell death patterns in hepatic ischemia-reperfusion injury (HIRI). The 20.7 KB DOCX file contains results from bulk and single-cell RNA-seq analyses of four public datasets (GSE151648, GSE14951, GSE12720, GSE171539). It identifies 25 differentially expressed genes and 5 hub genes, including THBS1 and CD47, linked to macrophage-hepatocyte crosstalk.

Use Cases

• Validating hub genes (THBS1, MAP1LC3B, PPP1R15A, CXCL8, ZC3H12A) for risk prediction models in HIRI based on the described machine learning analysis.
• Investigating macrophage-hepatocyte crosstalk via the THBS1-CD47 axis based on the mechanistic findings described.
• Analyzing enrichment of specific programmed cell death patterns (anoikis, immunogenic cell death, NETosis, Netotic cell death, pyroptosis) in high-risk patient groups.
• Cross-referencing single-cell transcriptomic patterns of programmed cell death in HIRI samples based on the 12 distinct patterns identified.

Strengths

• Analysis integrates four public Gene Expression Omnibus (GEO) datasets (GSE151648, GSE14951, GSE12720, GSE171539).
• Identifies 25 consistently upregulated differentially expressed genes and 5 hub genes from machine learning.
• Validates findings at both bulk and single-cell transcriptomic levels and with in vivo/in vitro experiments.

Limitations

• Row count and column-level documentation are unknown; field semantics must be inferred after download.
• The dataset is very small (20.7 KB), indicating it is likely a summary table rather than raw expression data.
• Data may reflect bias inherent to the specific public GEO datasets used in the original study.

Provenance

Source

figshare, author Manly Xie. Data derived from public GEO datasets.

Collection Method

Integrated analysis of bulk and single-cell RNA-seq data from GEO, combined with machine learning and experimental validation.

Time Range

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Freshness

Last updated 2026-05-19 04:22:42; freshness should be verified.

Geography

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