Helicobacter Pylori Virulence and Resistance Profiles from 159 Gastric Cancer Tissues

159 H. pylori-positive gastric cancer tissue samples were analyzed for 21 molecular features, including virulence gene presence, expression, and antimicrobial resistance mutations. The data was produced by Oliver Mbuthia and last updated in May 2026. It identifies two dominant bacterial molecular states associated with clinicopathological characteristics.

Use Cases

• Clustering bacterial molecular states based on integrated virulence and resistance features mentioned in the description.
• Associating microbial profiles with tumor differentiation and anatomical distribution as described in the results.
• Hypothesis generation for risk stratification based on the identified Colonizer and Resistant Inflammatory profiles.

Strengths

• Includes 159 histologically confirmed H. pylori-positive gastric cancer tissue samples.
• Integrates 21 standardized molecular features, including gene carriage, expression, and resistance mutations.
• Profiles are statistically associated with clinicopathological features like histological detectability (p < 0.001).

Limitations

• Row count for the underlying data is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 39.8 KB, indicating limited scope.

Provenance

Source

Oliver Mbuthia via figshare.

Collection Method

Analysis of tissue samples using polymerase chain reaction–based assays and unsupervised clustering.

Freshness

Last updated 2026-05-19 05:44:16; freshness should be verified.