SF-1 Lineage PitNETs: Single-Cell and Bulk RNA Sequencing Data

Integrated single-cell and bulk RNA sequencing data from Steroidogenic Factor-1 (SF-1) lineage Pituitary Neuroendocrine Tumors (PitNETs). The dataset was uploaded by Changxi Han to figshare and last updated on 2026-04-22. It identifies a proliferative tumor subgroup characterized by high expression of the gene RGS4.

Use Cases

• Identify molecular subgroups within SF-1 lineage PitNETs based on integrated scRNA-seq and bulk RNA-seq data.
• Validate RGS4 as a biomarker correlated with tumor size and proliferation index.
• Investigate the RGS4-p53 axis as a potential therapeutic target for pituitary adenomas.
• Perform differential expression analysis to discover other candidate drivers in SF-1 lineage PitNETs.

Strengths

• Dataset integrates both single-cell and bulk RNA sequencing data, as described.
• License is CC-BY-4.0, permitting open sharing and adaptation.
• Last updated on 2026-04-22, indicating recent availability.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 9.8 KB, suggesting limited scope or summary-level data.

Provenance

Source

figshare

Collection Method

Integrated analysis of scRNA-seq and bulk transcriptomic datasets from SF-1 lineage PitNETs.

Freshness

Last updated 2026-04-22 05:49:46