TRPM7 Phosphosite Analysis from 569 Phosphoproteomics Datasets

Akhina Palollathil published a dataset on June 1, 2026, detailing phosphoproteomic analysis of the TRPM7 channel-kinase. The analysis integrates 569 phosphoproteomics profiling datasets and 116 differential abundance datasets. It identifies 55 Class I phosphosites in TRPM7, including 13 novel sites, and proposes potential upstream regulatory kinases.

Use Cases

• Identify novel phosphorylation sites on TRPM7 based on the reported 13 previously unreported sites.
• Investigate the role of TRPM7 in cell cycle regulation based on its association with G2/M phase transition functions.
• Study potential kinase-substrate relationships using the list of identified upstream kinases like PRKCD and MAP4K4.
• Analyze the functional specialization of TRPM7 interactors in processes like stem cell maintenance and mRNA splicing.

Strengths

• Analysis is based on a large-scale integration of 569 phosphoproteomics profiling datasets.
• Identifies 55 Class I phosphosites, including 13 that are novel, providing a specific resource.
• Associates TRPM7 functions with specific cellular processes like chromatin remodeling and apoptosis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.
• The 839.0 KB file size suggests a limited scope, likely containing summary results rather than raw experimental data.

Provenance

Source

Akhina Palollathil via figshare

Collection Method

Co-differential detection-based analysis of publicly available phosphoproteomics datasets.

Freshness

Last updated 2026-06-01 05:25:22; freshness should be verified.