Mouse Duodenal Transcriptome and Microbiome Data for Ochratoxin A Ferroptosis Study

769 differentially expressed genes and microbiome profiles from mice exposed to Ochratoxin A (OTA) for seven days. The dataset, authored by Shaokat Ali and last updated in April 2026, integrates transcriptomic and 16S rRNA sequencing data to investigate duodenal damage and gut dysbiosis. It is a 19.6 KB DOCX file containing analysis results, licensed under CC-BY-4.0.

Use Cases

• Modeling ferroptosis pathways based on the 26 overlapping ferroptosis-regulating genes identified.
• Analyzing gut microbiome shifts based on altered Bacteroidota abundance and pathogenic enrichment described.
• Investigating redox and iron homeostasis based on downregulated key genes SLC7A11, GSTM1, CP, and SLC40A1.
• Correlating histological damage markers with transcriptomic signatures of duodenal injury.

Strengths

• Integrates multiple data modalities: transcriptomics, 16S rRNA sequencing, and biochemical assays as described.
• Identifies 769 differentially expressed genes (134 upregulated, 635 downregulated) with specific ferroptosis links.
• Experimental design is detailed, including OTA dosage (2 mg/kg/day) and a 7-day exposure period.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (19.6 KB), suggesting it contains summary results rather than raw sequencing data.

Provenance

Source

figshare

Collection Method

Data generated from mouse model exposure, histological analysis, transcriptomics, and 16S rRNA sequencing.

Time Range

Experimental period covered seven days of exposure.

Freshness

Last updated 2026-04-13 04:35:19; freshness should be verified.

Geography

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