Systematic Review of Adipose-Derived Cell Therapies for Knee Osteoarthritis, 2015-2025

A systematic review document summarizing 19 randomized controlled trials published between 2015 and 2025 on intra-articular adipose-derived cell therapies for knee osteoarthritis. The review, authored by Joelington Dias Batista and published on figshare in 2026, evaluates the efficacy, structural effects, and safety of treatments like ADSCs, SVF, and MFAT. It reports on outcomes including pain, function, and imaging-based structural changes.

Use Cases

• Comparing the efficacy of different adipose-derived cell therapies (ADSCs, SVF, MFAT) based on the review's synthesis of clinical trial results.
• Analyzing safety profiles and adverse event rates for intra-articular cell therapies mentioned in the review.
• Investigating the relationship between pain/functional outcomes (e.g., WOMAC, KOOS scores) and structural changes (e.g., MRI findings) as discussed in the review.

Strengths

• The review is based on 19 randomized controlled trials, a specific and rigorous study design.
• It covers a defined time range of publications from 2015 to 2025.
• The document is licensed under CC-BY-4.0, allowing for open sharing and reuse.

Limitations

• The dataset is a 27.0 KB DOCX file, indicating a very limited textual summary rather than raw trial data.
• Column-level documentation for any underlying data is absent; field semantics must be inferred from the review text.
• Row count for any potential tabular data within the document is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Joelington Dias Batista.

Collection Method

Systematic review of randomized controlled trials identified through searches of PubMed, Embase, Scopus, and Web of Science.

Time Range

Studies published between 2015 and 2025.

Freshness

Last updated 2026-04-22 12:54:14; freshness should be verified.