pH-Dependent Antifungal Effects of Butyrate on Candida Albicans

A 2026 study by Fiona C. Dresel investigates the pH-dependent antifungal activity of sodium butyrate against Candida albicans. The research examines effects on growth, hyphal transition, respiration, biofilm formation, mitochondrial function, ROS accumulation, and calcium homeostasis under neutral and acidic (pH 4.0) conditions. The dataset comprises the underlying results and analysis supporting these findings.

Use Cases

• Analyze the relationship between pH condition and fungicidal activity of sodium butyrate against Candida albicans.
• Model the impact of sodium butyrate on hyphal morphogenesis and biofilm formation as virulence traits.
• Investigate correlations between mitochondrial depolarisation, reactive oxygen species levels, and cell death under acidic treatment.
• Assess histone deacetylase inhibitory activity as an early cellular effect of sodium butyrate exposure.

Strengths

• Data is recent, with a last update in March 2026.
• Study design includes physiologically relevant gut pH conditions (neutral and pH 4.0).
• Research examines multiple cellular response mechanisms, including growth, respiration, and calcium homeostasis.

Limitations

• Dataset is very small, with a file size of only 16.2 KB, indicating limited raw data.
• The primary data is embedded within a DOCX document, requiring extraction for computational analysis.
• No explicit column or row structure is provided, complicating direct tabular analysis.

Provenance

Source

figshare, authored by Fiona C. Dresel.

Collection Method

Experimental laboratory study assessing Candida albicans responses to sodium butyrate under controlled pH conditions.

Time Range

Study published in 2026.

Freshness

Last updated 2026-03-23.