Table 1_Investigating the therapeutic mechanism of Puerarin in vascular dementia: an integ

Hongmei Tang uploaded a research document on figshare in April 2026. The document details an integrated study combining network pharmacology and experimental validation to investigate the therapeutic mechanism of Puerarin in vascular dementia. It includes results from behavioral testing, molecular analyses, and pathway interrogation.

Use Cases

• Analyze therapeutic pathways for vascular dementia based on the described Toll-like receptor and NF-κB signaling.
• Validate network pharmacology predictions using the described experimental methods like ELISA, qPCR, and Western blotting.
• Study the effects of a natural compound on cognitive deficits based on behavioral testing results.
• Investigate the relationship between neuroinflammation and blood-brain barrier integrity based on the described molecular analyses.

Strengths

• The document provides a detailed methodological description combining network pharmacology and multiple experimental validation techniques.
• It includes specific results, such as the identification of 17 putative active compounds and 100 overlapping targets.
• The conclusion presents a clear mechanistic pathway (TLR4/MyD88/NF-κB) supported by experimental data.

Limitations

• The dataset is a single 12.4 KB DOCX file, indicating a very limited scope and likely a summary document rather than raw data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for data-driven analysis.

Provenance

Source

figshare

Collection Method

Likely compiled from a research study.

Freshness

Last updated 2026-04-29 05:37:32; freshness should be verified.