ARHGEF12 Genotype and Netarsudil Response in 1,844 Glaucoma Subjects

Anusha Mamidipaka's dataset on figshare, last updated May 8, 2026, investigates the therapeutic response to the Rho-kinase inhibitor netarsudil in glaucoma subjects with the ARHGEF12 risk variant. It contains analysis of 1,844 African ancestry subjects with primary open-angle glaucoma (POAG), with netarsudil response evaluated in a subset of 66 subjects (114 eyes). The data compares baseline phenotypes and 12-month intraocular pressure changes across different ARHGEF12 genotype groups.

Use Cases

• Analyze the association between ARHGEF12 genotype and baseline glaucoma severity based on intraocular pressure and other ocular phenotypes.
• Evaluate pharmacogenetic predictors of netarsudil response based on 12-month intraocular pressure reduction data.
• Compare treatment outcomes across genotype groups using metrics like cup-to-disc ratio and visual field mean deviation mentioned in the results.

Strengths

• Includes data from 1,844 African ancestry subjects with POAG, a population of specific genetic interest.
• Contains longitudinal response data for a subset of 66 subjects (114 eyes) tracked over 12 months.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The authors describe the findings as preliminary and exploratory, noting the need for larger, treatment-naïve cohorts.
• The dataset is very small at 17.4 KB, indicating limited scope, likely containing summary results rather than raw patient-level data.

Provenance

Source

figshare, author Anusha Mamidipaka.

Collection Method

Clinical study analyzing subjects with POAG, comparing phenotypes and treatment response across genotype groups using generalized estimating equations.

Time Range

Study period includes a 12-month treatment follow-up; specific collection years are not stated.

Freshness

Last updated 2026-05-08 05:48:19; freshness should be verified.

Geography

Subjects are of African ancestry; specific geographic locations are not stated.