ITGA5 and SNAI2 Gene Expression Analysis in Oral Squamous Cell Carcinoma

A research document analyzing the role of integrin subunit α5 (ITGA5) in head and neck squamous cell carcinoma (HNSCC). The study, authored by Yanan Li and last updated on 2026-05-21, investigates ITGA5's expression, prognostic significance, and its functional mechanism via SNAI2 in promoting oral squamous cell carcinoma (OSCC) progression. The dataset is a 12.3 KB document shared under a CC-BY-4.0 license on figshare.

Use Cases

• Studying the correlation between ITGA5 expression and patient prognosis in HNSCC based on the described analysis.
• Investigating the role of ITGA5 in regulating epithelial-mesenchymal transition (EMT) in cancer cells as mentioned in the functional study.
• Exploring the interaction between ITGA5 and SNAI2 in promoting cell proliferation and metastasis in OSCC models.
• Identifying potential co-expression genes of ITGA5 for network analysis in HNSCC.

Strengths

• Document is shared under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.
• The research includes functional validation through knockdown and overexpression experiments, as described.
• Analysis integrates data from multiple public biological information databases, as stated in the description.

Limitations

• The dataset is a 12.3 KB DOCX file, indicating a very limited scope, likely a summary table or manuscript.
• Row count and column-level documentation are absent; data structure must be inferred after download.
• Description metadata is limited; actual data quality and completeness require manual inspection.

Provenance

Source

figshare, authored by Yanan Li.

Collection Method

Analysis performed using a series of public biological information databases, followed by functional studies.

Freshness

Last updated 2026-05-21 05:47:42; freshness should be verified.