Kangxianhuanji Formula Study on Acute Pulmonary Fibrosis

A research study investigating the molecular mechanisms of Kangxianhuanji Formula (KHF) in treating acute exacerbation of idiopathic pulmonary fibrosis. The study used a bleomycin-induced mouse model, network pharmacology, proteomics, and molecular docking to identify GLUT1 as a core target and rutin as a key bioactive component. The dataset is a 13.5 KB document authored by Siyuan Zhu and uploaded to figshare in April 2026.

Use Cases

• Analyze the therapeutic effects of herbal formulas on fibrosis based on histopathology and inflammatory assessments
• Study GLUT1-mediated glycolysis pathways in pulmonary disease based on proteomics and network pharmacology findings
• Identify bioactive compounds in traditional prescriptions based on LC-MS/MS and molecular docking results
• Validate predicted drug targets in animal models based on DARTS and CETSA methodologies

Strengths

• The study employs multiple validation methods, including in vivo mouse models, network pharmacology, proteomics, and cellular assays.
• The dataset is openly licensed under CC-BY-4.0, allowing for reuse and redistribution.

Limitations

• The dataset is a 13.5 KB document; its scope is limited to the textual description of the study and likely contains no raw experimental data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Research study involving experimental and computational methods.

Freshness

Last updated 2026-04-24 04:22:35; freshness should be verified.