Laetiporus Sulphureus Polysaccharides Effects on Colitis in a Mouse Model

A research article from figshare authored by Sharafat Ali, last updated April 15, 2026. The study investigates the protective mechanisms of Laetiporus sulphureus polysaccharides (LSP) in a dextran sulfate sodium-induced colitis mouse model. It details results on disease activity, colon length, cytokine profiles, and 16S rRNA sequencing of gut microbiota.

Use Cases

• Analyzing the relationship between polysaccharide administration and disease activity index reduction based on the described ~60% decrease.
• Studying gut microbiota remodeling based on the described changes in taxa like Escherichia-Shigella and Lactobacillus.
• Investigating immune response modulation based on the described cytokine profiles for TNF-α, IL-6, IL-10, and TGF-β.
• Examining epithelial barrier restoration based on the described changes in mucin-2 and tight junction protein expression.

Strengths

• Specific quantitative results are reported, including a ~60% reduction in disease activity index and fold-changes for various biomarkers.
• The study employs multiple analytical methods (HPLC, FTIR, SEM, immunofluorescence, IHC, 16S rRNA sequencing) as described.
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a 14.9 KB DOCX file containing a research article, not a structured data table; column-level documentation is absent.
• Row count is unknown, which may limit suitability assessment for direct machine learning applications.
• The data is derived from a specific mouse model study, which may limit direct applicability to human contexts.

Provenance

Source

figshare, author Sharafat Ali.

Collection Method

Experimental study using BALB/c mice, biochemical assays, immunofluorescence, IHC, and 16S rRNA sequencing.

Time Range

The study period is not specified.

Freshness

Last updated 2026-04-15 05:46:41.

Geography

The geographic origin of the study is not specified.