Porcine m6A Methylation and Gene Expression Landscape During PEDV Infection

A 2026 study by Xia Dong maps the transcriptome-wide landscape of N6-methyladenosine (m6A) methylation in porcine cells infected with Porcine Epidemic Diarrhea Virus (PEDV). The dataset identifies 803 differentially methylated peaks, 674 differentially expressed m6A-methylated genes, and 345 differentially expressed genes (DEGs). It provides a theoretical framework for research on m6A methylation's role in antiviral immunity.

Use Cases

• Identify candidate genes associated with antiviral response based on differential m6A methylation and expression profiles.
• Analyze functional enrichment of host genes in immune and metabolic pathways during PEDV infection.
• Study the role of specific m6A regulators (e.g., METTL3, FTO) in viral infection dynamics.
• Investigate correlations between RNA methylation patterns and gene expression changes in a pathogenic context.

Strengths

• Includes results from joint analysis of RNA-seq and MeRIP-seq, identifying 16 differentially expressed genes with m6A methylation.
• Provides specific counts for identified features: 803 differentially methylated peaks and 345 differentially expressed genes.
• Released under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (14.9 KB), suggesting it may contain summary results rather than raw sequencing data.

Provenance

Source

Xia Dong via figshare

Collection Method

Transcriptome-wide m6A methylation profiling (MeRIP-seq) and gene expression profiling (RNA-seq) of porcine cells with and without PEDV infection.

Time Range

Study published in 2026.

Freshness

Last updated 2026-05-18 05:35:54; freshness should be verified.

Geography

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